A novel candidate HIV vaccine vector based on the replication deficient Capripoxvirus, Lumpy skin disease virus (LSDV)
نویسندگان
چکیده
منابع مشابه
Evaluation of Humoral and Cell-mediated Immunity of Two Capripoxvirus Vaccine Strains against Lumpy Skin Disease Virus
Background and Aims: Prevention of Lumpy skin disease (LSD) in cattle is heavily dependent on vaccination. Since the genetic structure of LSD virus has the close relatedness with other Capri-pox virus (CaPV). Therefore, the use of vaccine strains of CaPV derived from sheep and goat would be useful to protect cattle against LSD. Materials and Methods: The susceptible calves of dairy farms were ...
متن کاملGenome of lumpy skin disease virus.
Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of LSDV. The 151-kbp LSDV genome consists of a central coding region bounded by identical 2.4 kbp-inverted terminal repeats and contains 156 putative genes. Comparison of LSDV with chordopoxviruses of othe...
متن کاملElectron microscopic studies on lumpy skin disease virus type "Neethling".
This technique has also been used extensively in studies on the structure of pox viruses. Horne & Wildy (1963) have reviewed the results obtained by various investigators working with this group of viruses. The more recently published findings of Buttner, Giese, Muller & Peters (1964) and Peters, Muller & Buttner (1964) suggest that the viruses of the pox group can be divided into the following...
متن کاملEarly and late transcriptional phases in the replication of lumpy-skin-disease virus.
Approximately 71 of the estimated 145 kilobase pairs of the genome of the South African isolate of lumpy-skin-disease virus, Neethling strain, was cloned into the plasmid vector pBluescribe. Selected clones were used in Northern blot analysis to investigate the replication cycle of the virus. The synthesis of early mRNA was initiated immediately after infection, and continued for approximately ...
متن کاملCloning, Expression and Purification of a Novel Multi-epitopic HIV-1 Vaccine Candidate: A Preliminary Study on Immunoreactivity
Introduction : Designing an effective vaccine against human immunodeficiency virus (HIV)-1 is a global health priority . Multi-epitope vaccines offer several potential advantages that may be promising in case of mutable divergent pathogens such as HIV-1. Herein, a multiepitopic recombinant protein containing various HIV-1 antigens was expressed in E. coli cells and its immunogenicity in combi...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2011
ISSN: 1743-422X
DOI: 10.1186/1743-422x-8-265